At the beginning, "holist" is a philosophic Greek concept (holos = the Unit). It refers to a concept of globality, in opposition to the reductionistic step of last century, i.e. it is impossible to observe a phenomenon without taking account of its environment, observer included. The Holiste Laboratories and development aims a research and a development for total and natural methods in the field of health and wellbeing. It is interested in sciences of ecology and the products being able to bring individual or collective solutions to limit pollution and to preserve its effects - or to fight them. Holiste, who manufactures and markets in international excusivity the apparatus "Bol d'Air", works in close cooperation, since 1989, with its inventor, René Jacquier. In 2002, Holiste got out in a new adventure with the development and the launching of a new working method and of motor activity without effort: the Jean Frelat method.