Human values driven by innovation

From the outset, Holiste's mission has been to create a fertile and innovative environment to promote a holistic and ecological approach to life in the fields of plant, animal and human health.

Aware of the emerging need for an ecological transition, we wanted to make the link between health and biodiversity, and to be agents of change.

This implies strong values to be respected throughout the life of the company, through its choices and behaviour, in terms of creativity, environmental, economic, societal and social quality.

An eco-design approach, methods that respect biology and physiology, and economically viable management are the essential pillars.

We are motivated by our multi-disciplinary work.

We have forged close links with inventors, engineers, manufacturers, scientists and healthcare professionals.

We continue to develop strong partnerships with other organisations in an open ecosystem where the synergy of skills is at the service of living beings.

Our team is driven by the desire to provide answers and solutions tailored to the needs of our customers. It has put its collective intelligence at the service of its mission and its commitment to creating tomorrow.

The Bol d'air as a starting point

Our history

René Jacquier, a visionary inventor

René Jacquier, a chemical engineer, was responsible for major discoveries in the fields of light, matter and biosynthesis. Improving and normalising cell oxygenation to boost the vitality of living beings and their natural defences was his major preoccupation.

His work with major pharmaceutical groups in Brazil on antibiotics, hormones, enzymes, etc. enabled him to study an enormous diversity of molecules essential to human health.

In 1946, he perfected a method of oxygenation, without added oxygen, using molecules derived from pine resin, transformed into oxygen carriers. A forward-looking solution for living and breathing in an age of pollution.

Our history

Creation of Holiste

On 22 June 1989, the newspaper Libération ran a special edition entitled "La Terre perd la boule" ("The Earth is losing its marbles"). In it, all the ecological disasters that have now been confirmed are described.

More specifically, it showed a mother giving her child "the oxygen feed", using a mask and a small bottle of gas. The scene takes place in Mexico City, at an altitude of 2,240 metres. The air there is highly polluted. This woman thought she was doing something good for her child, but she risked damaging the integrity of the alveoli in her lungs.

For Marie-Laure Delanef, the Bol d'air solution for providing oxygen simply and naturally to the organisms that need it was an obvious choice.

Holiste was created in November 1989.

Our history
Années 2000

Soaring sales

In 2002, Europe 1 devoted two hours to René Jacquier. He captivated thousands of listeners. The switchboard was overwhelmed, and many users testified. Under this impetus, Holiste took a quantum leap forward, developing its technology and embarking on a new scientific approach, thanks to Professor Decristofaro and Professor Pietrobelli, who were impressed by this method of oxygenation without added oxygen.

In 2008, Béatrice Mercier, PhD in the biology of oxygenation, defended her doctoral thesis on the Bol d'Air at the University of Dijon. After 5 years of research, the oxygenating and protective action of the Bol d'air Jacquier method against free radicals was confirmed.

A multidisciplinary approach led to new observations and publications.

Our history

The BioGemme department is born

Pine resin contains the active ingredients of the Bol d'air Jacquier oxygenation method, Holiste's flagship product.

It is the essential raw material for the development and sustainability of its business.

To ensure the quality, traceability and quantity of its supplies, Holiste is taking an environmental approach and developing an innovative ecological harvesting method, which is likely to preserve the forest and the large coniferous trees, and protect the fauna as well as the health of the gemmeur.

BioGemme then offers co-products to industrialists committed to the ecological transition, to create new eco-sourced materials.

Our history

A breath of fresh air for the horse

As part of its commitment to environmental health, Holiste is interested in the well-being of animals, the source of their balance and health. Holiste is making its first adaptation of the Bol d'Air for a large animal.

This product, the result of numerous observations, has been acclaimed by breeders, riding schools, horse care professionals... and by the horse itself, which loves it!

Our history

1st participation in the Made In France trade fair

Holiste becomes ambassador for the Bourgogne-Franche-Comté region at the Made in France trade show. The health situation, far from dampening public and professional interest in Bol d'air, reinforced their awareness that the method offered a real solution to better overall health. This craze has led to further progress for the company.

Our history

An inspiring connection

Holiste continues to develop strong partnerships, in an open ecosystem where the synergy of skills is at the service of new ambitions. One of the company's major ambitions is the creation of a zero-waste environmental model. "We want to add value to the entire life cycle of our products!

A biomimetic invention

Marie-Laure Delanef met René Jacquier in 1989.

This visionary chemist used methods of thought and observation that enabled him to tackle a wide range of fields, from classical, organic and dye chemistry to physics and biology. He was interested in biosynthesis and made numerous discoveries in this field.

His wish was to normalise the oxygenation of sick people to improve their vitality and regenerative capacities. Aware that increasing the amount of oxygen breathed was not the solution, he observed nature and drew inspiration from it.

"We used to send people out into the fresh air to regain their health. That was the starting point for my analysis. Vegetation, sunlight, chlorophyll function - these natural processes generate very active oxygen. The most profitable places were those with coniferous trees. They emanate terpenes, components of pine resin and the turpentine that comes from it. That's what I was looking for. During the breathing process, oxygen from the air combines with haemoglobin. The terpenes in maritime pine, unsaturated and able to bind them more finely, would make oxygen more available to the cell.

Based on this observation, he invented the biocatalytic oxygenation method and produced his first Bol d'air prototypes in 1947.

Why Holiste?

The name reflects our commitment to a holistic, natural approach to life.

Holiste comes from holism, derived from the ancient Greek holos, meaning the whole, the totality.

The holistic approach considers all living things as a whole, as a set of complex systems that interact with each other. It is opposed to a reductive vision that has often led science to "cut it up into independent pieces". This perspective accompanies our approach to innovation.